منابع مشابه
The nude rat as an orthotopic model for cervical cancer.
OBJECTIVE The purposes of this study were to establish intracervical tumors of the nude rat as an orthotopic experimental model for human cervical cancer and to preliminary evaluate the effects of the adenoviral vector, Ad5CMV-p53, on orthotopic cervical tumor size. METHODS Human cervical cancer SiHa and ME-180 cells were injected into the cervix of the nude rat. Four days later, 1 x 10(9) pl...
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Purpose. The ability to establish consistent human tumor xenografts in experimental animals is a crucial part of preclinical investigations.The goal of this study was to develop a method of establishing a human tumor xenograft in the leg of a nude rat for evaluation of new surgical and molecular methods of treatments of human extremity sarcoma.Methods and results. Initial attempts to produce sa...
متن کاملIrradiated nude rat model for orthotopic human lung cancers.
The development of improved animal models for biological and preclinical studies of human lung cancer is important because lung cancer is the leading cause of cancer death in the United States. To determine whether the Rowett nude rat could serve as an orthotopic (organ-specific) model of this disease, nude rats (CR: NIH-RNU), with and without 500 rads of prior gamma-irradiation, were implanted...
متن کاملThe athymic nude rat. III. Natural cell-mediated cytotoxicity.
Homozygous rnuirnu and heterozygous +/mu rats were investigated and compared with each other for the existence of natural cell-mediated cytotoxicity. Investigated were total, adherent, and nonadherent cell populations from spleen, peritoneal cavity, and mesenteric lymph node. The natural killer (NK) cell activity was measured in a 4-hr SICr-release assay with a xenogeneic murine YAC lymphoma ta...
متن کاملHormonal effects on glioblastoma multiforme in the nude rat model.
OBJECT The authors studied the effect of gender and hormonal status on survival in nude rats implanted with human glioblastoma multiforme (GBM) cell lines. METHODS Nude rats received intracerebral implants of either wild-type U87MG cells or U87MG cells transfected with the gene for endothelin-1 (U87/ET-1). In the initial study, survival was compared in males and females for each of the two ce...
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ژورنال
عنوان ژورنال: Cellular Microbiology
سال: 2006
ISSN: 1462-5814,1462-5822
DOI: 10.1111/j.1462-5822.2005.00658.x